Prenatal vitamins are formulated for pregnancy and fetal development—they focus on nutrients like folate and iron for a growing baby.

Rise & Rest are formulated for pre-conception and egg quality. We include CoQ10 (50mg) and other antioxidants specifically to support mitochondrial function in developing eggs — nutrients that aren't included in standard prenatals.

Think of it this way:

• Prenatals = Pregnancy nutrition
• Rise & Rest = Egg quality & pre-conception preparation

Once you are pregnant, we recommend switching to a prenatal multivitamin. While all ingredients are natural, clean, and safe during pre-conception, we recommend switching to a comprehensive prenatal once you receive a positive pregnancy test. Prenatals contain pregnancy-specific nutrients like additional folate, iron, DHA, and choline needed for fetal development.

Rise & Rest contain clinically-studied nutrients that support fertility through multiple mechanisms — from cellular energy production in developing eggs to hormone regulation and stress management. Here's how each ingredient works:

CoQ10 (Coenzyme Q10) is a powerful antioxidant that your eggs need for energy production. Each egg contains more mitochondria than any other cell in your body, and these "cellular batteries" require CoQ10 to generate ATP — the energy needed for egg maturation, fertilization, and early embryo development.

Research shows CoQ10 supplementation improves ovarian response in women with diminished ovarian reserve, increasing the number of retrieved oocytes, fertilization rates, and high-quality embryos. (PMID: 29587861) Studies in both animal and human models demonstrate that CoQ10 restores mitochondrial function in aging eggs and may reverse age-related decline in egg quality and quantity. (PMID: 26111777) A 2024 meta-analysis of over 1,500 women undergoing IVF found that CoQ10 pretreatment significantly increased clinical pregnancy rates, improved embryo quality, and reduced cycle cancellation rates. (PMID: 39129455)

Magnesium (Four Bioavailable Forms in Rise & Rest) is an essential mineral involved in over 300 enzymatic reactions in your body, including six of the eight steps that convert food into cellular energy. This makes it critical for egg quality and overall reproductive function.

Research demonstrates that successful IVF outcomes are associated with higher magnesium levels in pre-stimulation blood samples, and magnesium supplementation in previously infertile women resulted in all 12 participants conceiving within eight months of normalizing their red blood cell magnesium levels. (PMID: 8054261, PMID: 26675754) Magnesium helps regulate fertility hormones including FSH and supports progesterone production — both essential for healthy ovulation and implantation. (PMID: 28869206)

Vitamin D3 functions as a hormone in your body, and vitamin D receptors are found in reproductive tissues including the ovaries, uterus, and placenta. Adequate vitamin D levels are associated with improved ovarian response, better embryo quality, and higher pregnancy rates in women undergoing fertility treatments.

Research shows that vitamin D influences follicle-stimulating hormone levels, egg maturation, and endometrial receptivity. (PMID: 22275473) Women with sufficient vitamin D levels undergoing IVF have been shown to have higher clinical pregnancy rates compared to those with vitamin D deficiency. (PMID: 25121462) A systematic review found that vitamin D supplementation improved reproductive outcomes in infertile women, particularly in those with PCOS and diminished ovarian reserve. (PMID: 35458211)

Methylated B Vitamins (B6, B9, B12) are essential for one-carbon metabolism — the biochemical pathway that supports DNA synthesis, methylation, and cell division during egg development and early embryo formation. Methylated forms (like 5-MTHF instead of folic acid) are critical because 40-50% of people have genetic variations that impair their ability to convert synthetic forms into active forms.

Clinical research demonstrates that supplementation with 5-methyltetrahydrofolate and vitamin B12 is associated with higher numbers of mature oocytes, improved fertilization rates, and increased clinical pregnancy and live birth rates in women undergoing assisted reproduction. (PMID: 34762110) Studies show that B vitamin status directly correlates with embryo quality, with higher riboflavin and folate levels associated with increased high-quality embryos and clinical pregnancy rates. (PMID: 36438768) MTHFR genetic variations are linked to a woman's potential to produce healthy embryos, making methylated B vitamin supplementation particularly important. (PMID: 16679164)

Organic Holy Basil (Ocimum sanctum) is a powerful adaptogen that helps your body manage stress by modulating the hypothalamic-pituitary-adrenal (HPA) axis — the system that controls cortisol release. Chronic stress and elevated cortisol can disrupt ovulation, hormone balance, and fertility.

Clinical trials show that holy basil extract significantly reduces perceived stress, lowers cortisol levels, and improves sleep quality in adults experiencing stress. (PMID: 36185698) The active compounds in holy basil (eugenol, ursolic acid, rosmarinic acid) work by regulating cortisol secretion and supporting the central nervous system, which influences the cognitive stress response. (PMID: 37141281) Animal studies demonstrate that holy basil reduces stress-induced elevations of corticosterone and other stress hormones while improving hormonal balance. (PMID: 26899341)

In summary: each ingredient in Rise & Rest works synergistically to create optimal conditions for egg development during the critical 90-day maturation window. By supporting mitochondrial function, reducing oxidative stress, balancing hormones, and managing the body's stress response, these nutrients help optimize your fertility from the cellular level up.

References:
PMID: 29587861, 26111777, 39129455, 8054261, 26675754, 28869206, 22275473, 25121462, 35458211, 34762110, 36438768, 16679164, 36185698, 37141281, 26899341

Your body treats fertility as a "luxury" — when you're stressed, sleep-deprived, or running on empty, your reproductive system takes a back seat to survival. Here's exactly how stress, sleep, and energy affect your ability to conceive, and why addressing all three is critical during your fertility journey.

Stress & Cortisol: The Fertility Disruptor

When you're stressed, your body releases cortisol — the primary stress hormone. While short-term cortisol release is normal and protective, chronic stress keeps cortisol elevated, and this has direct consequences for your fertility.

Elevated cortisol disrupts the hypothalamic-pituitary-gonadal (HPG) axis, which regulates your reproductive hormones. High cortisol suppresses gonadotropin-releasing hormone (GnRH), preventing your brain from signaling your ovaries to release FSH and LH — the hormones needed for ovulation. This can delay or prevent ovulation entirely, leading to irregular or missed periods. (PMID: 37344406) Research shows that stress-induced cortisol production directly inhibits estradiol biosynthesis in the ovaries, which reduces both the quality and quantity of eggs retrieved during fertility treatments. (PMID: 27013390)

Studies demonstrate that women with elevated cortisol levels experience impaired egg maturation, reduced fertilization potential, and lower pregnancy rates. In IVF cycles specifically, acute and chronic stress resulted in fewer eggs retrieved, fewer successfully fertilized embryos, fewer embryo transfers, lower live birth rates, and lower birth weights. (PMID: 29250769) Importantly, stress doesn't just affect current cycles — chronic stress generates oxidative stress in the ovaries, which induces granulosa cell and oocyte apoptosis (cell death), deteriorating egg quality over time. (PMID: 27013390)

Sleep Quality: The Forgotten Fertility Factor

Sleep isn't just about feeling rested — it's when your body performs critical cellular repair, hormone regulation, and energy restoration. Poor sleep quality directly impacts IVF outcomes and natural conception rates.

Multiple studies show that women with poor sleep quality (measured by the Pittsburgh Sleep Quality Index) have significantly lower clinical pregnancy rates and live birth rates compared to women with good sleep quality. In one study of 263 women undergoing IVF, those with poor sleep quality had pregnancy rates of 65.1% versus 69.3% in women with good sleep, and live birth rates of 45.7% versus 50.5%. (PMID: 36261696) A systematic review and meta-analysis confirmed that sleep quality is significantly associated with IVF pregnancy rates. (PMID: 39924965)

Research shows that optimal sleep duration for fertility is 7-9 hours per night, with sleep timing also playing a crucial role. Women who went to bed around 10 PM and woke around 6 AM had the best fertilization rates, while going to bed too early or too late decreased fertilization rates by 12-13%. Women with night shift experience had a 30% decrease in implantation rates. (PMID: 35259255) Sleep duration under 7 hours per night is associated with impaired oocyte yield and embryo quality, while excessively long sleep (over 9-10 hours) may reduce the chance of clinical pregnancy. (PMID: 35259255, PMID: 36435629)

The mechanisms behind these effects include circadian rhythm disruption and the cortisol-melatonin relationship. Chronically elevated cortisol suppresses melatonin (your sleep hormone), creating a vicious cycle where stress disrupts sleep, and poor sleep increases cortisol — both of which impair fertility. (PMID: 39632025)

Cellular Energy: The Foundation of Egg Quality

Every biological process in your body requires energy in the form of ATP (adenosine triphosphate), and developing eggs are among the most energy-demanding cells in your entire body.

Mature human oocytes contain approximately 100,000 mitochondria — thousands of times more than sperm (50-75) or regular body cells (~2,000). This massive mitochondrial reserve exists because eggs need enormous amounts of ATP for maturation, fertilization, and to fuel early embryo development until the blastocyst stage. (PMID: 26343250) Since mitochondria in the early embryo don't replicate until after the blastocyst stage, all the energy for those first critical days of development comes exclusively from the egg's mitochondrial stores. (PMID: 26343250, PMID: 37240296)

Research demonstrates that mitochondrial dysfunction — characterized by decreased ATP production, reduced membrane potential, and accumulated mtDNA mutations — is significantly correlated with decreased oocyte quality and age-related fertility decline. (PMID: 39205088) Studies show that impaired ATP synthesis negatively affects chromosome segregation during meiosis, increases the risk of aneuploidy (chromosomal abnormalities), and compromises embryo viability. (PMID: 20933103) The ability of mitochondria to balance ATP supply and demand is considered the most critical factor for both fertilization competence in oocytes and developmental competence in embryos. (PMID: 20933103)

When your body is under chronic stress or sleep deprivation, it prioritizes energy for immediate survival functions, reducing the cellular energy available for the energetically "expensive" process of producing high-quality eggs. (PMID: 25150832)

The Bottom Line: Stress, sleep, and cellular energy aren't separate issues — they're interconnected systems that all impact your fertility. Chronic stress elevates cortisol, which disrupts ovulation and damages egg quality. Poor sleep compounds stress while disrupting the hormone cycles needed for conception. And when your body lacks the cellular energy (ATP) to support egg development, quality suffers. This is why Rise & Rest work synergistically: by supporting stress management, promoting restorative sleep, and fueling mitochondrial energy production, they help create optimal conditions for your fertility during the critical 90-day egg maturation window.

References:
PMID: 37344406, 27013390, 29250769, 36261696, 39924965, 35259255, 36435629, 39632025, 26343250, 37240296, 39205088, 20933103, 25150832

Yes — you can't turn back the clock on your ovarian reserve, but you can optimize the quality of the eggs you have.

Egg quality isn't just about your age — it's about creating optimal conditions at the cellular level during the 90-day window when your eggs are actively developing. Rise & Rest work through multiple scientifically-proven mechanisms to protect developing eggs from damage and support the energy production they need to mature properly. Here's exactly how:

1. Protecting Eggs from Oxidative Stress

Think of oxidative stress as "cellular rust" — when your body produces more reactive oxygen species (ROS) than it can neutralize with antioxidants, these unstable molecules damage your cells, including developing eggs. This imbalance is one of the primary drivers of declining egg quality.

Research demonstrates that oxidative stress in the follicular fluid (the environment surrounding your eggs) is directly associated with decreased oocyte quality, lower fertilization rates, and poorer embryo development. (PMID: 27026099) Studies show that follicular fluid from successfully fertilized oocytes has elevated antioxidant capacity and lower levels of pro-inflammatory molecules, while follicles with high oxidative stress produce poor-quality embryos with lower implantation potential. (PMID: 36362229) In fact, oxidative stress can cause DNA fragmentation in eggs, induce abnormal meiosis (the cell division process eggs undergo), disrupt mitochondrial function, and trigger oocyte apoptosis (cell death). (PMID: 22672653, PMID: 34121193)

The ingredients in Rise & Rest — particularly CoQ10, magnesium, vitamin D, and adaptogens — function as powerful antioxidants that neutralize ROS and reduce oxidative damage during the critical egg maturation period. (PMID: 32707921) Clinical studies show that antioxidant supplementation during IVF significantly improves oocyte maturation markers and reduces oxidative stress biomarkers in follicular fluid. (PMID: 19645016)

2. Fueling Mitochondrial Energy Production

Your eggs are the most energy-demanding cells in your body, containing up to 100,000 mitochondria each — that's 50 times more than a typical body cell. These mitochondria must produce enormous amounts of ATP to power egg maturation, fertilization, and the first days of embryo development before the blastocyst stage.

Research confirms that the ability of mitochondria to balance ATP supply and demand is the most critical factor for fertilization competence in oocytes and developmental competence in embryos. (PMID: 20933103) Studies show that impaired mitochondrial function and decreased ATP levels in eggs are directly correlated with poor oocyte quality, failed fertilization, chromosomal abnormalities, and developmental arrest in early embryos. (PMID: 26343250, PMID: 19585665)

CoQ10 is essential for the electron transport chain in mitochondria — it literally carries electrons between complexes to generate ATP through oxidative phosphorylation. Without adequate CoQ10, your eggs cannot produce sufficient energy for proper maturation. (PMID: 26111777) Magnesium serves as a cofactor in six of the eight steps that convert food into cellular energy, making it indispensable for ATP production. (PMID: 8054261) The B vitamins in Rise function as coenzymes in energy metabolism pathways, directly supporting the massive energy demands of developing eggs. (PMID: 36438768)

3. Supporting Proper Chromosome Segregation

One of the biggest causes of failed implantation and miscarriage is chromosomal abnormalities (aneuploidy) in eggs. The process of completing meiotic division in eggs — positioning and segregating chromosomes correctly — is one of the most energy-demanding processes within the oocyte and requires massive amounts of ATP.

Studies demonstrate that age-related decline in ATP levels is associated with high rates of aneuploidy because eggs lack sufficient energy to properly assemble and disassemble the microtubules needed for correct chromosome separation. (PMID: 35094043) Research shows that eggs with mitochondrial dysfunction exhibit increased meiotic spindle abnormalities and chromosomal misalignment, resulting in aneuploid embryos that cannot develop properly. (PMID: 26111777) By restoring mitochondrial function and ATP production, CoQ10 and other mitochondrial nutrients help ensure eggs have the energy required for accurate chromosome segregation. (PMID: 29587861)

4. Breaking the Stress-Inflammation-Oxidative Damage Cycle

Chronic stress doesn't just disrupt ovulation — it creates a cascade that directly damages egg quality through multiple pathways. Elevated cortisol induces oxidative stress, triggers inflammation, and impairs mitochondrial function in developing eggs.

Research shows that psychological stress increases ROS production in the ovary and reduces the antioxidant capacity of follicular fluid, creating oxidative stress that deteriorates oocyte quality. (PMID: 27026099) Studies demonstrate that stress-induced cortisol elevation reduces estradiol production in granulosa cells (the cells that surround and nourish developing eggs), which impairs follicle growth and egg maturation. (PMID: 27013390) The adaptogens in Rise & Rest — particularly holy basil — help modulate the HPA axis to reduce cortisol production and break this destructive cycle. (PMID: 37141281)

5. Optimizing the Follicular Microenvironment

The quality of your eggs isn't determined in isolation — it's heavily influenced by the follicular fluid environment in which they develop. This fluid contains nutrients, hormones, and antioxidants that directly impact oocyte maturation.

Clinical studies show that follicular fluid with optimal antioxidant capacity and balanced inflammatory markers produces higher-quality eggs with better fertilization potential and embryo development. (PMID: 36362229) Research demonstrates that vitamin D receptors are present in ovarian tissue and that adequate vitamin D levels improve the follicular microenvironment, enhance ovarian response, and support egg quality. (PMID: 25121462) The nutrients in Rise & Rest help optimize this critical environment during the 90-day maturation window.

The Bottom Line: Egg quality isn't fixed — it's modifiable during the 90-day maturation window. Rise & Rest work at the cellular level to protect developing eggs from oxidative damage, fuel the massive energy demands of egg maturation, support accurate chromosome segregation, reduce stress-induced damage, and optimize the follicular environment. This comprehensive approach addresses the root causes of poor egg quality rather than treating symptoms, giving your eggs the best possible conditions to develop during their critical maturation period.

References:
PMID: 27026099, 36362229, 22672653, 34121193, 32707921, 19645016, 20933103, 26343250, 19585665, 26111777, 8054261, 36438768, 35094043, 29587861, 27013390, 37141281, 25121462

Ideally, start 3 months (90 days) before you plan to actively try.

Why? An egg takes 3-4 months to mature before ovulation. The egg you ovulate this month started developing three months ago. To give your eggs the best possible support, you want those developing eggs bathed in antioxidants and optimal nutrition during their entire maturation process.

Already trying? Start now. Every cycle you support your eggs is a cycle with better quality.

Absolutely. The same 12-week supplement protocol applies before IVF or egg freezing — you want your eggs in the best possible condition before retrieval.

Many fertility clinics recommend CoQ10 (200-600mg), vitamin D (2000+ IU), and antioxidants in the months leading up to an egg retrieval. Rise & Rest provide these nutrients at optimal levels.

When to stop: Continue Rise & Rest up until a positive pregnancy test, then switch to a prenatal.

First, we're so sorry for your loss.

Improving egg quality through antioxidant support may help reduce the risk of chromosomal errors and miscarriage, especially for women with a history of pregnancy loss.

That said: Rise & Rest are not a guarantee against miscarriage—many losses are due to chromosomal issues unrelated to nutrition. But supporting egg quality with targeted antioxidants during the 90-day maturation window gives your eggs the best possible foundation.

Yes — while all ingredients are natural, clean and safe and have been used for centuries in traditional and ayurvedic medicine, there is insufficient research on its safety during pregnancy.

So here's our recommended protocol:

• Pre-conception: Rise & Rest
• Positive pregnancy test: Switch to a comprehensive prenatal with DHA, iron, choline, and pregnancy-specific nutrients
• Postpartum: Consider our Recovery formulation

The nutrients behind Rise & Rest support the hormonal balance that underlies healthy cycles:

• B vitamins support hormone synthesis
• Vitamin D supports ovulation and insulin sensitivity
• Magnesium helps regulate fertility hormones
• Adaptogens regulate cortisol (which can disrupt cycles)

If you have severely irregular cycles or anovulation, it's recommended to work with a healthcare provider for targeted support. Feel free to reach out to us at hello@lunher.com for personalized guidance.

This is normal. Rise & Rest work at the cellular level—you're not going to "feel" your mitochondria improving or your eggs getting better antioxidant protection.

What you might notice over time:

• More consistent energy (from RISE)
• Better sleep quality (from REST)
• More balanced stress response
• More regular cycles (if previously irregular)

What you won't notice:

• Immediate changes to egg quality (this happens over 90 days)
• Instant fertility (supplements support your body, they don't guarantee conception)

Trust the process. Give your body the full 12 weeks to see benefits unfold.

Rise & Rest are generally well-tolerated by >99% of our customers. However, when starting, some may experience:

• Mild digestive upset when starting (take with food)
• Vivid dreams from magnesium or adaptogens in Rest (not harmful, usually subsides)
• Energy changes in the first week as your body adjusts